Topics with new or revised events include Immune system (TLR4 cascade, MyD88:Mal cascade on plasma membrane, and MyD88-independent cascade), Cell Cycle (Condensation of prometaphase chromosomes, Mitotic prophase: MASTL facilitates mitotic progression, and Resolution of sister chromatid cohesion), Extracellular matrix organization (Collagen degradation, Elastic fibre formation, and Assembly of collagen fibrils and other multimeric structures), Metabolism (Inositol Phosphate Metabolism, Arachidonic acid metabolism, Mitochondrial Iron-Sulfur Cluster Biogenesis, and Phosphate bond [...]

New in Version 41 is the topic Cellular responses to stress, including Regulation of Hypoxia-inducible Factor by oxygen. Topics with new or revised events include Immune System (MHC Class II mediated antigen processing & presentation), Metabolism (Abacavir transport and metabolism, Glycerophospholipid biosynthesis, Glycosaminoglycan metabolism, Linoleic acid and alpha-linolenic acid metabolism, O2/CO2 exchange in erythrocytes, PI Metabolism, Reversible hydration of carbon dioxide, and Activation [...]

Reactome has a new RESTful interface, which has the ability to expose pathway data in Reactome as XML and JSON.

If you would prefer to use our old website, the classic Reactome home page, displaying the reactionmap (or “starry sky”) is still available. The old website is still functional but will no longer being maintained, and will become progressively more out of date. We recommend that you use the new Reactome homepage.

Recently, Reactome released a new website and an updated suite of data analysis tools. Many users of our pathway analysis tools have asked if we will continue to support the skypainter analysis tool. The skypainter tool is available at http://www.reactome.org/cgi-bin/skypainter2. We are also working on resurrecting the classic Reactome website. The reactionmap (or “starry sky”) and [...]

Reactome provides orthology-based pathway projections from human to other species. We are currently reviewing the list of target species. Please let us know if you would like to include a species that’s not in the planned target species list.

Reactome is committed to providing access to high-quality pathway information and useful data analysis tools. With this in mind, we are actively soliciting comments from the research community in order to assess community needs. We are interested to hear about your experience with Reactome, and would like to know a bit about your background and [...]

The Editorial Calendar shows work now under way to expand the Reactome knowledgebase, organized by planned date of public release on this web site. The Calendar also shows the Reactome curator who is managing the work on each topic. For more information, including information about how you can participate in the Reactome editorial process,email the curator.

Changes include collapsable panes, dynamic event hierarchy, and graphical representation of reactions.

The Reactome SkyPainter tool allows the overlay of protein or gene identifiers on the reaction map. SkyPainter 2 now available at the Reactome site, also lets users visualize microarray data overlaid on the reaction map, including time series data.