As a first step toward systematically annotating human disease processes in Reactome, a new topic, Disease, has been created. It contains the existing HIV, Influenza, Botulinum neurotoxicity, Amyloids, and Diabetes pathways with the new Signaling by EGFR in Cancer. As described in the users’ guide, pathway diagrams have been revised to show the interplay between disease and normal processes and a new color scheme has been implemented to differentiate the two. Topics with new or revised events include Immune System (ISG15 antiviral mechanism, Prolactin receptor signalling, Defensins, and Interleukin-7 signalling), Metabolism (Sulfur amino acid metabolism, Sphingolipid metabolism, O-linked glycosylation of mucins, and Serine biosynthesis), Signal transduction (Signaling by ERBB2 and Signaling by ERBB4), and Gene expression.

Annotations of chicken (Gallus gallus) DNA replication and repair, toll receptor signaling, and metabolism available at gallus.reactome.org with limited browsing and data analysis tools are now also available, with full functionality, in the Reactome pathway browser (switch species to “Gallus gallus”).

KP Ray and R Stephan are our external authors. A Ferrer, V Goffin, H Greulich, RC Harris, AM McDermott, LM Neckers, J Puck, F Rauscher, S Savas, W Xu, F Zeng, and DE Zhang  are our external reviewers.