Version 36 includes the new topics Meiotic recombination and Mycobacterium tuberculosis biological processes. Topics in this release that contain new or revised and updated events include: Signaling in the immune system (Interleukin-2 signaling, and Interleukin-6 signaling), Diabetes pathways (Adipogenesis), Membrane Trafficking (Endosomal Sorting Complex Required For Transport (ESCRT), and Gene expression. K Ray and R Stephan are our external authors in this release. E Bolcun-Filas, P Cohen, K Holloway, A Lyndaker, F Rauscher, S Rose-John, M Rush, JK Sethi, J Schimenti, E Strong, A Villarino, and D Warner are our external reviewers. In collaboration with WikiPathways, Reactome has established a custom human pathway portal. Reactome is actively soliciting feedback through a User Survey in order to assess community needs.