Reactome: A Curated Pathway Database

Fertilization (R-HSA-1187000.1)

Species Homo sapiens

Summation

Mammalian fertilization comprises sperm migration through the female reproductive tract, biochemical and morphological changes to sperm, and sperm-egg interaction in the oviduct. Although the broad concepts of fertilization are well defined, our understanding of the biochemical mechanisms underlying sperm-egg binding is limited.

Locations in the PathwayBrowser
Additional Information
GO Biological Process single fertilization (0007338)
Literature References
pubMedId Title Journal Year
16467268 Analysis of the human sperm proteome Ann N Y Acad Sci 2005
12479616 The state of the union: the cell biology of fertilization Nat Cell Biol 2002